2004 Study on Dihydrocodeine is first in the U.S. in more than 40 years.

A comparison study of Panlor® SS and Lorcet® 10/650 was conducted including 58 patients with primary dysmenorrhea. Both single-dose and multi-dose assessments were made under randomized, double-blinded, active comparator-controlled conditions. The results were very straightforward :

• Both analgesics provided meaningful efficacy
• Both analgesics were well tolerated
• There was no significant difference in side effects

Dihydrocodeine has more than 40 years of clinical experience.

DHC avoids aspirin and NSAID-related complications such as bleeding, GI upset, and prolonged bleeding time. 3, 14, 15

Panlor's unique combination provides powerful relief - and not just from the opioid analgesia. Caffeine potentiates the acetaminophen by up to 40%. The ingredients in Panlor® may provide unique opioid dose-sparing effects to reduce adverse reactions. 9, 10, 11

The most frequent adverse reactions include lightheadedness, dizziness, drowsiness, sedation, nausea and vomiting. Not recommended for patients 12 years of age or under. The CNS-depressant effects may be additive with that of the CNS-depressants.

In high doses or in sensitive patients, dihydrocodeine may produce dose-related respiratory depression.

3. Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Gilman AG, Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, eds. Goodman and Gilman's: The Pharmacological Basis of Therapeutics. 9th ed. McGraw-Hill 1996; 254:877-885.
9. Drugs for pain. In: Abramoweiz M, ed. Med Lett Drugs Ther. New Rochelle, NY; The Medical Letter, 1993; 35:1-5.
10. Beaver WR. Aspirin and Acetaminophen as constituents of analgesic combinations. Arch Intern Med. 1981; 141:292-300.
11. Acute Pain Management Guideline Panel. Acute Pain Management: Operative or Medical Procedures and Trauma. Clinical Practice Guideline. Rockville, MD. 1992: US Department of Health and Human Services publication AHCPR 92-0032.
14. Jick H. Effects of aspirin and acetaminophen in gastrointestinal hemorrhage. Arch Intern Med. 1981; 141: 316-321.
15. Mielke CH Jr. Comparative effects of aspirin and acetaminophen on homeostasis. Arch Intern Med. 1981; 141: 305-310.


Panlor® SS is a registered trademark of Pamlab, L.L.C. All rights reserved. Lorcet® 10/650 is a registered trademark of Forest Pharmaceuticals, Inc. All rights reserved.